tumor necrosis factor-α and interleukin-1- β polymorphisms in pre-eclampsia
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Tumor Necrosis Factor-α and Interleukin-1- β Polymorphisms in Pre-Eclampsia
Background: Pre-eclampsia is the most common critical condition during pregnancy. Plasma concentrations of tumor necrosis factor-alpha (TNF-α) and interleukin-1-beta (IL-1β) increase in pregnant women with pre-eclampsia, compared to normal pregnant women. Objective: To investigate the polymorphisms of IL-1β (C+3954T), TNF-α (G- 308A), and (G-238A) in preeclemptic women northeastern Iran. Me...
متن کاملTumor Necrosis Factor-α and Interleukin-1-β Polymorphisms in Pre-Eclampsia.
BACKGROUND Pre-eclampsia is the most common critical condition during pregnancy. Plasma concentrations of tumor necrosis factor-alpha (TNF-α) and interleukin-1-beta (IL-1β) increase in pregnant women with pre-eclampsia, compared to normal pregnant women. OBJECTIVE To investigate the polymorphisms of IL-1β (C+3954T), TNF-α (G-308A), and (G-238A) in pre-eclemptic women in northeastern Iran. M...
متن کاملassociation of single nucleotide polymorphisms in the human tumor necrosis factor-α and interleukin 1-β genes in patients with pre-eclampsia.
pre-eclampsia is a pregnancy-specific syndrome that may be dangerous especially to the fetus. different cytokines have been found to be elevated in women with pre-eclampsia and may have possible roles in the development of this disorder. alleles of the interleukin-l-beta (il-lβ) and tumor necrosis factor alpha (tnf-α) genes are associated with pr-eeclampsia in several studies in different popul...
متن کاملSerum Tumor Necrosis Factor–α in Pre Eclampsia
Cy tok ines a re ma jo r con t r ibu to r s in pa thogenes i s o f p re eclampsia. Serum TNF-α was determined in 10 normal and 30 pre-eclamptic pregnant females with special reference to maternal age, parity and levels of mean ar ter ia l b lood pressure . TNF-α was determined us ing sandwich ELISA techn ique . Se rum TNF-α l eve l in normal p regnan t f emales was 9 .3 ± 0 .56 pg /ml , whi le ...
متن کاملAssociation of single nucleotide polymorphisms in the human tumor necrosis factor-α and interleukin 1-β genes in patients with pre-eclampsia.
Pre-eclampsia is a pregnancy-specific syndrome that may be dangerous especially to the fetus. Different cytokines have been found to be elevated in women with pre-eclampsia and may have possible roles in the development of this disorder. Alleles of the interleukin-l-beta (IL-lβ) and tumor necrosis factor alpha (TNF-α) genes are associated with pr-eeclampsia in several studies in different popul...
متن کاملPolymorphisms in the tumor necrosis factor-alpha gene in Turkish women with pre-eclampsia and eclampsia.
The genetic background predisposing pregnant women to pre-eclampsia/eclampsia (PE/E) is still unknown. The aim of the current study was to investigate whether there is an association between the TNF-alpha-308 and 850 polymorphisms and PE or eclampsia. In this study, 40 cases of eclampsia, 113 cases of PE and 80 normotensive control cases were genotyped for the TNF-alpha-G-308A and C-850 polymor...
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عنوان ژورنال:
iranian journal of immunologyجلد ۱۳، شماره ۴، صفحات ۳۰۹-۳۱۶
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